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  • Prof. Michal Granot

    Prof. Michal Granot

    The Cheryl Spencer Department of Nursing
    CV File,
Associate Professor
Research Areas
  • The assessment of pain perception and processing;
  • Women’s health, mainly the effect of culture on health outcomes;
  • The health reform process in Israel and the effect of the changes in health care organizations on the development of new managerial roles for nurses.
Michal Granot, RN, PhD, is an associate professor at the Faculty of Social Welfare & Health Sciences, Department of Nursing, University of Haifa, Israel. Her clinical background as a midwife has shaped her research activity that focuses mainly on pain and women health by investigating the etiology, mechanism, and expression of pain modulation processes. As a member of the Haifa Pain Group at the Laboratory of Clinical Neurophysiology, Rambam Health Care Campus, Prof. Granot collaborate on projects that aim to promote transformational “lab to clinic” studies, encompassing mechanism-based tests that represent pain perception and modulation processing. She devoted part of her laboratory work to the conceptualization of a model that depicts the variability of pain experience and the plasticity of the nociceptive system. 
Prof. Granot developed and use experimental-induced pain tests that mirrors inhibitory and facilitatory pain modulation pathways as well as brain activity, which involves in pain perception. She lead and take part in research projects that aim to evaluate and quantify mechanisms involved with normal, as well as altered, pain modulation responses. Her research combined assessment of  brain processes during painful events, such as pain-evoked potentials, as well as the autonomic and psych-cognitive aspects of pain. Such advanced psychophysical and neurophysiological approaches enable clinicians and researchers to attain view of an individual's pain as obtained in early acute pain patients, can explain one’s risk to develop chronic pain disorders. Prof. Granot collaborate with well-known key experts in the fields of pain and gynecology with special focus on the domain of chronic pelvic pain disorders such as provoked vestibulodynia and investigate the effect of such pain on the quality of intimate relationships.
She is interest in women’s pain disorders and the mechanisms in which the ovarian hormones modulate pain processing and highlight the effect of cultural, and pain-related personality variables on pain manifestation as well as on health outcomes. She also explore pain complaints among women who were exposed to sexual abuse. Prof. Granot merge theoretical knowledge with current clinical issues and practices that require a multidimensional investigation approach in order to promote personalized medicine, based on the individual’s pathogenesis and needs. Another aspect of her activity is understanding the phenomenon of absence of pain experience in situations of injury or acute disease. For example, altered pain perception in patients with silent ischemic heart diseases. These diverse studies contain the potential to enable pain clinicians to create evidence-based guidelines for the management of chronic pain conditions, based on individually-tailored pain mechanisms.


Johns Hopkins
Hebrew University
Department/Name of Lab Head
School of Hygiene and Public Health,
Faculty of Medicine
Faculty of Medicine
Department of Nursing
Post-doctoral studies


Articles in Refereed Journals
1.    Granot, M., Perelman, R., Sprecher, E., Tenenbaum, G., Barzily, D., & Vardi, P. (1994). The role of beta cell maturity in the development of type I Diabetes Mellitus. Israeli Journal of Medical Science, 30, 22-25
2.    Ravid. C., Spitzer, A., Tamir, B., Granot, M., & Noam, R. (1995). Internal body perceptions of Ethiopian Jews who immigrated to Israel. Western Journal of Nursing Research, 17, 630-646. 
3.    Spitzer, A., Kesselring, A., Ravid, C., Tamir, B., Granot, M., & Noam, R. (1996). Learning about another culture: Project and curricular reflections. Journal of Nursing Education, 35, 322-328.
4.    Granot, M., Spitzer, A., Aroian, J.K., Ravid, C., Tamir, B., & Noam, R. (1996). Pregnancy and delivery practice and beliefs of Ethiopian Immigrant women in Israel. Western Journal of Nursing Research, 18, 299-312.
5.    Eisenberg, E., & Granot, M. (1998). Education for care givers in pain: Do the right thing right. Pain Clinic, 10, 245-252.
6.    Granot, M., Yarnitsky, D., Itszkovits-Eldor, J., Granovsky, Y., Peer, E., & Zimmer, E. Z. (2001). Pain perception in women with dysmenorrhea. Obstetrics & Gynecology, 98, 407-411.
7.    Granot, M., Buskila, D., Granovsky, Y., Sprecher, E., Neumann, L., & Yarintsky, D. (2001). Simultaneous recording of late and ultra-late pain evoked potentials in Fibromyalgia. Clinical Neurophysiology, 112, 1881-1887.
8.    Granot, M., Friedman, M., Yarnitsky, D., & Zimmer E.Z. (2002). Enhancement of the perception of systemic pain in women with vulvar vestibulitis. BJOG: An International Journal of Obstetrics and Gynaecology, 109 (8), 863-866.
9.    Granot, M., Lowenstein, L., Yarnitsky, D., & Zimmer, E.Z. (2003). Postcesarean section pain prediction by preoperative experimental pain assessment. Anesthesiology, 98, 1422-1426. This paper has been acknowledged by an editorial review
10.         Granot, M., Sprecher, E., & Yarnitsky, D. (2003). Psychophysics of phasic and tonic heat pain stimuli by quantitative sensory testing in healthy subjects. European Journal of Pain, 7, 139-143.
11.         Bowie, J., Sydnor Dobson, K., & Granot, M. (2003). Spirituality and care of prostate cancer patients: A Pilot Study. Journal of the National Medical Association, 95, 951-954.
12.         Drach-Zahavy, A., Somech, A., Granot, M., & Spitzer, A. (2004). Can we win them all? Benefits and costs of structured and flexible innovation-implementations. Journal of Organizational Behavior, 25, 217-234.
13.         Granot, M., Goldstein-Ferber, S., & Azzam, Z. (2004). Gender differences in the perception of chest pain. Journal of Pain and Symptom Management, 27, 149-155.]
14.         Lowenstein, L., Vardi, Y., Deutsch, M., Fridman, M., Gruenwald, I., Granot, M., Sprecher, E., & Yarnitsky, D. (2004). Vulvar vestibulitis severity – assessment by sensory and pain testing modalities. Pain, 107, 47-53.
15.         Granot, M., Friedman, M., Yarnitsky, D., Tamir, A., & Zimmer, E. Z. (2004). Primary and Secondary Vulvar Vestibulitis Syndrome: Systemic pain perception and psychophysical characteristics. American Journal of Obstetrics and Gynecology, 191, 138-142. /
16.         Granot, M., Zimmer, E.Z., Friedman, M., Lowenstein, L., & Yarnitsky, D. (2004). Association between quantitative sensory testing, treatment choice and subsequent pain reduction in Vulvar Vestibulitis Syndrome. Journal of Pain, 5, 226-232.
17.         Baron-Epel, O., Granot, M., Badarna, S., & Avrami, S. (2004). Perceptions of breast cancer among Arab Israeli women. Women & Health, 40, 101-116.
18.         Bowie, J. V., Sydnor, K. D., Granot, M., & Pargament, K. L. (2004). Spirituality and coping among survivors of prostate cancer. Journal of Psychosocial Oncology, 22, 41-56.
19.         Granot, M., & Lavee, Y. (2005). Psychological factors associated with perception of experimental pain in Vulvar Vestibulitis Syndrome. Journal of Sex and Marital Therapy, 31, 285-302.] .
20.         Goldstein-Ferber, S., Granot, M., & Zimmer, E.Z. (2005). Catastrophizing labor pain compromises later maternity adjustments. American Journal of Obstetrics and Gynecology, 192, (3) 826-831.]
21.         Granot, M. (2005). Personality traits associated with perception of noxious stimuli in women with Vulvar Vestibulitis Syndrome. Journal of Pain, 6, 168-173.
22.         Granot, M., & Nagler, R. (2005). Association between regional idiopathic neuropathy and salivary involvement as the possible mechanism for oral sensorial complaints. Journal of Pain, 6, 581-587.
23.         Granot, M., & Goldstein-Ferber, S. (2005). The roles of pain catastrophizing and anxiety in the prediction of post-operative pain intensity: A prospective study. Clinical Journal of Pain, 21, 439-445. doi: 10.1097/01.ajp.0000135236.12705.2d []
24.         Goldblatt, H., & Granot, M. (2005). Domestic violence among Druze women in Israel as reflected by health status and somatization level. Women & Health, 42(3), 19-36.
25.         Goldstein-Ferber, S., & Granot, M. (2006). The Association between Somatization and Perceived Ability: Roles in dysmenorrhea among Israeli Arab adolescents. Psychosomatic Medicine, 68, 136-142. doi: 10.1097/01.psy.0000197644.95292.00
26.         Lowenstein, L., Granot, M., Tamir, A., Glik, A., Deutsch, M., Jakobi, P., & Zimmer, E.Z. (2006). Efficacy of suppository analgesia in postabortion pain reduction. Contraception, 74, 345-348.
27.         Granot, M., Granovsky, Y., Sprecher, E., Nir, R.R., & Yarnitsky, D. (2006). Contact heat-evoked temporal summation: Tonic versus repetitive-phasic stimulation. Pain, 122, 295-305.
28.         # Strulov, L., Zimmer, E.Z., Granot, M., Tamir, A., Jakobi, P., & Lowenstein, L. (2007). Pain catastrophizing, response to experimental heat stimuli, and post–cesarean section pain. Journal of Pain, 8, 273-279.
29.         Granot, M., Khoury, R., Berger, G., Krivoy, N., Braun, E., Aronson, D., & Azzam, Z.S. (2007). Clinical and experimental pain perception is attenuated in patients with painless myocardial infarction. Pain, 133, 120-127.] 
30.         Granovsky, Y., Granot, M., Nir, R.R., & Yarnitsky, D. (2008). Objective correlate of subjective pain perception by contact heat evoked potentials. Journal of Pain, 9(1), 53-63. [IF =3.387, 33/156  
31.         Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008). Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter? Pain, 136(1-2), 142-149.
32.         Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.A., & Granot, M. (2008). Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk. Pain, 15, 138(1), 22-28.  
33.         Goldblatt, H., Granot, M., Admi, H., & Drach-Zahavi, A. (2008). The experience of being a shift manager in a hospital ward. Journal of Advanced Nursing, 63, 45–53.
34.         Weissman-Fogel, .I., Granovsky, Y.,  Crispel, Y.,  Ben-Nun A.,  Yarnitsky, D., & Granot, M. (2009). Enhanced pre-surgical pain temporal summation response predicts post-thoracotomy pain intensity during the acute postoperative phase. Journal of Pain, 10, 628-636.
35.         Granot, M. (2009). Can we predict persistent postoperative pain by testing preoperative experimental pain? Review article. Current Opinion in Anesthesiology, 22, 425-430. doi: 10.1097/ACO.0b013e32832a40e1
36.         van Lankveld, J.D.M., Granot, M., Weijmar Schultz, W. C. M., Binik, Y. M., Wesselmann, U., Pukall, C. F., Bohm-Starke, N.,&  Achtari, C. (2010).  Women’s sexual pain disorders. Journal of Sexual Medicine, 7(1 Pt 2), 615-631.
37.         Landau, R., Kraft, J. C., Flint, L. Y., Carvalho, B., Richebé, P., Cardoso, M., Lavand'homme, P., Granot, M., Yarnitsky, D., & Cahana, A. (2010). An experimental paradigm for the prediction of Post-Operative Pain (PPOP). Journal of Visualized Experiments, 27(35), 1671. doi: 10.3791/1671
38.         Halpern, O., Raz, I., Ben-Gal, L., Weizman,  Z., Or-Chen, K, & Granot, M. (2010). Prediction of perineal trauma during childbirth by assessment of Striae Gravidarum Score. Journal of Obstetric, Gynecologic, & Neonatal Nursing, 39, 292-297.
39.         Yarnitsky, D., Arendt-Nielsen, L., Bouhassira, D., Edwards, R. R., Fillingim, B. R., Granot M., Hansson, P.,  Lautenbacher, S., Marchand, S., & Wilder-Smith, O. (2010). Conditioned Pain Modulation (CPM): Recommendations on terminology and practice of psychophysical DNIC testing. European Journal of Pain, 14(4), 339.
40.         Nisenblat, V., Engel– Eger, B., Ohel, G., & Granot, M. (2010). The association between supra-physiological levels of Estradiol and response pattern to experimental pain. European Journal of Pain, 14, 840-846.  
41.         Granot, M., Zisman, Y., Ram, E., Goldstick, O., & Yovell, Y. (2011).  Characteristics of attachment style in women with dyspareunia. Journal of Sex and Marital Therapy, 37, 1–16.
42.         #Nir, R.R., Granovsky, Y., Yarnitsky, D., Sprecher E., & Granot, M. (2011). A psychophysical study of endogenous analgesia: The role of the conditioning pain in the induction and magnitude of conditioned pain modulation. European Journal of Pain, 15, 491-497.  
43.         Granot, M., Somer, S., Zisman-Ilani, Y., Beny, A., Sadger, R., Mirkin, R., Moont, R., & Yovell, Y. (2011). Characteristics of response to experimental pain in sexually abused women. Clinical Journal of Pain, 27, 616-622. doi:10.1097/AJP.0b013e3182132963]
44.         Drach-Zahavi, A., Goldblatt, H., Granot, M., Hirshmann, S., & Kostinsky, H. (2011). Control: Patients' Aggression in Psychiatric Settings. Qualitative Health Research, 21, 43-53.
45.         Granot, M., & Wismman-Fogel, I. (2012). The effect of post-surgical neuroplasticity on the stability of systemic pain perception: a psychophysical study. European Journal of Pain, 16(2), 247-55.   
46.         Nir, R. R., Yarnitsky, D., Honigman, L., & Granot M.  (2012). Conditioned Pain Modulation is Reduced due to a Placebo Effect which Decreases the Subjective Perception of the Conditioning Stimulation. Pain, 153(1), 170-176.]  
47.         Yarnitsky, D., Granot, M., Nahman-Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012). Conditioned pain modulation predicts efficacy of duloxetine in painful diabetic neuropathy. Pain, 154(6), 1193-1198.
48.         Ortner, C. M., Granot, M., Richebe, P., Cardoso, M., Bollag, L., & Landau, R. (2013). Preoperative Scar Hyperalgesia and Post-operative Pain in Women Undergoing Repeat Cesarean Delivery. European Journal of Pain, 17(1), 111-123. 
49.         Wilson, H., Carvalho, B., Granot, M., & Landau, R. (2013). Evaluation of the temporal stability of conditioned pain modulation in healthy women over four menstrual cycles at the follicular and luteal phases.  Pain, 154 (12), 2633-2638.
50.         Afanasiev, S., Aharon, Y., & Granot M. (2013). Personality type as a predictor for depressive symptoms and reduction in quality of life among stroke survivals. American Journal of Geriatric Psychiatry, 21(9), 832-839.
51.         Nahman-Averbuch, H., Yarnitsky, D., Granovsky,Y., Gerber, E., Dagul, P., & Granot, M. (2013). The effect of psychophysical parameters on the conditioned pain modulation response. Scandinavian Journal of Pain, 4(1), 10-14.
52.         Kremer, R.,  Granot, M., Yarnitsky, D., Crispel, Y., Fadel, S., Best, L., & Nir, R. R. (2013). The Role of Pain Catastrophizing in the Prediction of Acute and Chronic Postoperative Pain. The Open Pain Journal, 6, 176-182.  doi: 10.2174/1876386301306010176
53.         Yarnitsky, D., Granot, M., & Granovsky, Y. (2014). Pain modulation profile and pain therapy: Between pro- and antinociception. Pain, 155(4), 663-665. doi: 10.1016/j.pain.2013.11.005
54.         Granot, M, Dagul P., Darawsha W, & Aronson, D. (2015). Pain Modulation Efficacy Affects Delay in Seeking Medical Help in Patients with Acute Myocardial Infarction. PAIN, 156(1), 192-198. doi: 10.1016/j.pain.0000000000000020
55.         Yarnitsky, D., Bouhassira, D.,  Drewes, A., Fillingim, RB.,  Granot, M., Hansson, P, Landau, R.,  Marchand, S., Matre, D., Nielsen, KB.,  Stubhaug, A., Treede, R. D., & Wilder-Smith, O. (2015). Recommendations on practice of conditioned pain modulation (CPM) testing. European Journal of Pain, 19, 805-806.
56.         Nahman-Averbuch, H., Yarnitsky, D., Sprecher, E., Granovsky, Y., & Granot, M. (2016). Relationship between personality traits and endogenous analgesia: the role of harm avoidance. Pain Practice, 16(1), 38-45.
57.         Reiner, K., Granot, M., Soffer, E., & Lipsitz, J. (2016). A Brief Mindfulness Meditation Training Increases Pain Threshold and Accelerates Modulation of Response to Tonic Pain in an Experimental Study. Pain Medicine, 17, 628-635.
58.         Carvalho B., Granot, M., Sultan, P., Wilson , H., & Landau , R. A. (2016). A Longitudinal study to evaluate pregnancy-induced endogenous analgesia and pain modulation. Regional Anesthesia and Pain Medicine, 41(2), 175-180. doi: 10.1097/AAP.0000000000000359
59.         Dishon Benattar, Y., Omar, M., Zusman, O., Yahav, D., Zak-Doron, Y., Altunin, S., Elbaz M.,  Granot, M.,  Leibovicil, L., & Paul, M. (2016). The effectiveness and safety of high-dose colistin: prospective cohort study. Clinical Infectious Diseases, 63(12), 1605-1612.
60.         Drach-Zahavy, D., Buchnic , L. & Granot, M., (2016). Antecedents and consequences of emotional work in midwifery: A prospective field study. International Journal of Nursing Studies, 60, 168-178. doi: 10.1016/j.ijnurstu.2016.04.014
61.         Grinberg, K., Granot, M., Lowenstein, L., Abramov, L., & Weissman-Fogel, I.  (2017). A common pro-nociceptive pain modulation profile typifying subgroups of chronic pelvic pain syndromes is interrelated with enhanced clinical pain. Pain, 158, 1021-1029. doi: 10.1097/j.pain.0000000000000869
62.         Granovsky, Y., Nahman-Averbuch, H., Khamaisi, M., & Granot, M. (2017). Efficient conditioned pain modulation despite pain persistence in painful diabetic neuropathy. Pain Reports, 2(3), e592. doi:  10.1097/PR9.0000000000000592
63.         Granot, M., Yovell, Y., Somer, E., Beny, A., Sadger, R., Uliel-Mirkin, R., & Zisman-Ilani, Y. (2018). Trauma, attachment style, and somatization: a study of women with dyspareunia and women survivors of sexual abuse. BMC Women’s Health,  18(1), 29. doi: 10.1186/s12905-018-0523-2
64.         Kuperman, P., Granovsky, Y., Granot, M., Bahouth, H., Fadel, S., Hyams, G., Ben Lulu, H., Aspis, O., Salame, R., Begal, J., Hochstein, D., Grunner, S., Honigman, L., Reshef, M., Sprecher, E., Bosak, N., Sterling, M., & Yarnitsky, D. (2018). Psyhophysical-psychological dichotomy in very early acute mTBI pain: A prospective study. Neurology, 91(10), e931-938. doi:10.1212/WNL.0000000000006120
65.         Grinberg, K., Granot, M., Lowenstein, L., Abramov, L., & Weissman-Fogel, I. (in press). Negative illness perceptions are associated with a pro-nociceptive modulation profile and augmented pelvic pain. Clinical Journal of Pain. Advance online publication. doi: 10.1097/AJP.0000000000000633.
66.         Goldblatt, H., Granot, M., & Zarbiv, E. (2019). “Death lay here on the sofa:” Reflections of young adults on their experience as caregivers of parents who died of cancer at home. Qualitative Health Research, 29, 533-544.
doi: 10.1177/1049732318800676 The first two authors contributed equally to this article.
67.   Granot, M., Dagul, P., Aronson, D. (2019).. Resting blood pressure modulate chest pain intensity in patients with acute myocardial infarction. Pain Reports. In press.
Articles or Chapters in Books which are not Conference Proceeding
1.         Yarnitsky, D., & Granot, M. (2006). Quantitative Sensory Testing. In F. Cervero & T. Jensen (Eds.), Handbook of clinical neurology (pp. 395-407). Amsterdam: Elsevier.
2.         van Lankveld,  J.D.M., Granot, M., Weijmar Schultz, W.C.M,. Binik, Y.M, Wesselmann, U., Pukall, K., Bohm-Starke, N., & Achtari, C. (2009). Women sexual pain disorders. In T.F. Lue, R. Basson, R. Rosen, F. Giuliano, S. Khoury, & F. Montorsi (Eds.), Sexual medicine: Sexual dysfunctions in men and women. Paris, France: Health Publications



Review of Articles for Refereed Journals
Year starting Journal
2004               Journal of Pain
2005               Anesthesiology
2005               Social Behavior and Personality
2006               PAIN
2005               Clinical Journal of Pain
2005               Journal of Psychosomatic Research
2006               Journal of Oral Rehabilitation
2007               Social Science and Medicine
2007               Western Journal of Nursing Research
2007               American Journal of Obstetrics and Gynecology
2008               European Journal of Obstetric & Gynecology and Reproductive Biology
2009               European Journal of Pain
2009               Journal of Psychosomatic Research
2010               International Journal of Gynecology and Obstetrics
*2011             The Journal of Sex Research
*2011             European Journal of Neuroscience
*2011             Neurotherapeutics
*2012             Cardiology
*2012             Israel Journal of Psychiatry
*2013             Contemporary Clinical Trials
*2013             Pain Medicine
*2014             PLOS ONE
*2014             Pain Practice
*2015             Mediators of Inflammation
*2016             Journal of Women's Health, Issues & Care
*2016             Pain Report
*2017             Neuroscience
*2017             Pain Research and Management
*2018             International Journal of Cognitive Therapy